Hemp Science

  • Can CBD Help Your Complexion? August 21, 2019 10:01 pm
    Is there anything substantive behind all the hype? Can CBD really protect, heal and restore the skin? What, if anything, does the science say about all this?
    daphnechurch
  • How to Make a CBD Topical for Healthy Skin August 21, 2019 5:07 pm
    The desire to anoint our skin with potions is as old as humanity itself. But is slathering an oily substance onto the skin really useful? And if so, what kind of skin elixir should one use, and why? Let’s look at how the skin protects and maintains itself, and what, if anything, can help it along.
    daphnechurch
  • CBD for Autism: The Therapeutic Promise August 21, 2019 4:57 am
    From Wholistic Research & Education Foundation.
    martin
  • Comments to the Food & Drug Administration on CBD and Cannabis August 19, 2019 11:03 pm
    Read Project CBD’s special report commenting on cannabis science to the FDA.
    admin
  • Neuro-oncology, Functional Medicine, and Medical Cannabis in Brazil August 14, 2019 11:23 pm
    In this edition of Cannabis Conversations, Project CBD speaks with Dr. Paula Dall’Stella, a leading cannabis clinician in San Paolo, Brazil.
    daphnechurch
  • CBD Science Update August 6, 2019 6:50 pm
    The 29th annual International Cannabinoid Research Society (ICRS) symposium, which convened last month in Bethesda, Maryland, featured new developments in CBD science that have far-reaching implications for many areas of medicine. Just over 500 participants from around the world attended the four-day conference, which included 65 oral presentations and nearly 200 posters covering a wide range of topics – with the caveat that researchers  had to present new, unpublished data. Harvard University scientist Staci Gruber shared encouraging results from “the first open-label to double-blind clinical trial” assessing the impact of a high-CBD, low-THC sublingual tincture in patients who experience moderate anxiety. None of the participants had been using any cannabinoid-based products prior to this study. Preliminary data “suggests significant improvement following four weeks of treatment when compared to baseline,” Gruber noted. “Specifically, findings suggest that the use of a custom-formulated, whole plant-derived high CBD sublingual tincture results in less severe anxiety and fewer anxiety-related symptoms.” After the completion of this open-label trial, Gruber intends to undertake a double-blind, placebo-controlled experiment that will generate “empirically sound data regarding the efficacy of sublingual CBD for anxiety.” CBD for hypertension Human subjects were also recruited for a CBD study at the University of Nottingham in the United Kingdom, where Saoirse E. O’Sullivan and her team examined the acute and chronic effects of cannabidiol on cardiovascular function. Previously, the Nottingham scientists had shown that “acute oral administration of CBD (600 mg) causes a reduction in blood pressure at rest and in response to stress.” But would tolerance develop with repeated dosing, thereby mitigating CBD’s hypotensive effect? To find out, twenty-six healthy males were given 600 mg CBD or a placebo orally for seven days in a randomized, placebo-controlled, double-blind, parallel study. The results were mixed. Measurements of resting blood pressure revealed that tolerance developed in response to chronic CBD administration, but CBD’s ability to lower blood pressure persisted during stress. “The reduction of arterial stiffness, and improvements in internal carotid artery blood flow and endothelial function after chronic CBD treatment, indicate a positive effect in vascular function that warrants further investigation in relevant patient populations,” O’Sullivan reported. Related storyCan CBD Help Your Condition? Preclinical promise ICRS 2019 included several talks devoted to clinical studies, but most of the CBD presentations showcased cutting-edge data based on preclinical research. The astonishing depth and range of this research underscored CBD’s versatile therapeutic potential. CBD for stroke. A meta-analysis by scientists at the University of Nottingham surveyed the effects of CBD in animal models of focal ischemic stroke. The study found that CBD limited the damage caused by induced brain injury: “CBD significantly reduces infarct volume and improved early functional outcome in experimental stroke in rodents.” University of Nottingham researchers also conducted hands-on, preclinical research that examined the anti-inflammatory and neuroprotective effects of cannabidiolic acid (CBDA), the raw, unheated version of CBD found in the cannabis plant. “Like CBD,” the researchers concluded, “CBDA is effective in reducing blood brain permeability and inflammation in a cellular model of stroke.” A compromised blood-brain barrier is a key factor in the secondary injury cascade that wreaks havoc on the brain during ischemia-reperfusion. CBD and CBDA restore BBB integrity by activating the 5-HT1a serotonin receptor, which also mediates CBD’s and CBDA’s anti-inflammatory effects. In Spain, neonatal animal experiments have paved the way for clinical testing of CBD on brain-damaged babies. CBD for substance abuse. There are no FDA-approved medications to treat cocaine addiction. So, researchers at the National Institute on Drug Abuse (NIDA) set out to assess CBD’s potential as an anti-cocaine remedy. The NIDA team gave CBD to cocaine-addicted rats and observed that systemic CBD treatment “shifted cocaine self-administration dose-response curve downward,” meaning that CBD tempered the rats’ craving for cocaine. “These findings suggest that CBD may have therapeutic utility to blunt rewarding effects of cocaine,” the NIDA researchers surmised. They also identified several molecular pathways whereby CBD conferred an anti-addictive effect on lab animals. These included the 5-HT1a serotonin receptor, the CB2 cannabinoid receptor, and an ion channel receptor known as “TRPV1” (pronounced trip-vee-one). When chemical “antagonists” were administered to block the signaling of these receptors, it negated CBD’s anti-addictive effects. CBD for prostate cancer. Italian scientists conducted follow-up research into the combined effect of two plant cannabinoids – CBD and cannabigerol (CBG) – on aggressive prostate cancer. A previous study had shown that 1:1 combination of CBD:CBG “significantly reduced tumor relapse in animals with hormone refractory status, and, in vitro, inhibited cell proliferation and induced apoptosis.” Their latest findings, as reported at ICRS, disclosed “how purified plant cannabinoids (CBD and CBG) affect the metabolic system of malignant tumors,” leading to “notable shifts of specific oncogenic related signaling pathways” in prostate cancer cells. This proves “the efficacy of phytocanabinoids as metabolic reprogramming agents,” which could form the basis of a breakthrough therapy for “highly malignant hormone refractory prostate cancer,” according to the Italian researchers. Scientists at Auburn University reached a similar conclusion regarding the antitumoral properties of CBD and THC, which inhibited prostate cell proliferation in a dose-dependent manner. This is encouraging news for the one out of nine men who will develop prostate cancer, the second leading cause of cancer death among American males. The preclinical experiment at Auburn suggests “that cannabinoids could be developed as novel therapeutic agents for the treatment of prostate cancer.” CBD for arthritis and gum disease. A team of Israeli, British, and American scientists analyzed the anti-inflammatory and painkilling effects of synthetic CBD in an animal model of arthritis. “CBD was shown to exert a potent analgesic effect” in preclinical research, which shed new light on CBD’s “anti-inflammatory mechanisms of action.” Another preclinical probe, conducted at the University of Leeds School of Dentistry in the UK, documented the potent anti-inflammatory effects of CBD on gum disease. The ability of CBD to modulate immune function “could provide possible therapeutic applications in the field of periodontal research,” the Leeds study concluded. Related story10 Tips for Buying CBD Oil CBD oil products There’s good reason to be excited about CBD’s potential health benefits, but a word of caution is necessary. Administering pure CBD to animals in a controlled laboratory setting is not the same as human consumption of a CBD oil product purchased from an unregulated internet storefront. The Prague-based International Cannabis and Cannabinoids Institute (ICCI) analyzed the quality of 70 hemp-derived CBD oil samples available in the European Union, and the results reported at the ICRS symposium were sobering, to say the least. Twenty percent of the samples contained less CBD than indicated on the label. THC was present in 89 percent of the samples, but in most cases no amount of THC was provided. And traces of highly toxic polycyclic aromatic hydrocarbons were found in all the oils tested, underscoring the strong need for better extraction and processing practices by CBD product-makers. Similar problems plague the CBD market in the United States. Inaccurate or incomplete CBD product labels undermine a consumer’s ability to make well-informed decisions. According to researchers at Thomas Jefferson University in Philadelphia and Washington University in St. Louis: “Recent studies have demonstrated that hemp-derived CBD products purchased over the internet are frequently mislabeled, contaminated, or are outright fraudulent (contain no cannabinoids whatsoever). Therefore, patients are more likely to receive medical benefit from products that are routed through state-licensed cannabis markets, where lab testing for CBD content is required.” Licensed cannabis dispensaries and delivery services also need to up their game and improve their product offerings. “Despite the obvious medical benefits, the availability of CBD-containing products in state-licensed retail stores is highly variable and surprisingly sparse. In one Pennsylvania store only 20 of products (39 or 196) contained CBD,” the U.S. researchers noted. “Results highlight the need for expanded patient access to CBD products.”
    daphnechurch
  • How Cannabis is Transforming Oklahoma August 1, 2019 12:00 am
    In 1997, Will Foster, then 38, was sentenced to 93 years in an Oklahoma state prison for growing a small cannabis garden in a locked bomb shelter under his home in Tulsa.
    zoe
  • Petition: Remove the Cannabis Ban for Athletes July 25, 2019 12:00 am
    Athletes for CARE is a nonprofit created by current and former professional athletes dedicated to using their influence for social change. They aim to protect the health and wellbeing of current and former athletes around the world.
    zoe
  • Cannabis for Contact Sports July 25, 2019 12:00 am
    Rugby is a physically demanding sport that requires both mental focus and a high tolerance for pain. It’s a full-contact tackle sport with no pads and no helmets, and the game flows freely with few stoppages – meaning continuous sprinting and collisions throughout the full 80 minutes of the match.
    zoe
  • Now This: Martin Lee and the CBD Revolution July 18, 2019 12:00 am
    This activist is the reason you know about CBD. Now he’s telling the history behind the cannabinoid.
    zoe
  • Is CBD Toxic to the Liver? July 11, 2019 8:00 am
    The huge popularity of cannabidiol (CBD), a non-intoxicating component of cannabis, has helped to destigmatize the plant and restore its reputation as an important medicinal herb.
    zoe
  • Do Cannabis Suppositories Work? July 4, 2019 12:00 am
    The back door is making a comeback - medically speaking. Cannabis oil suppositories have grown in popularity, but how and to what extent they actually work remains somewhat of a mystery.
    zoe
  • When CBD Isn't Enough to Treat Epilepsy June 27, 2019 12:00 am
    At night you might find Chelsea Leyland, a 31-year-old British celebrity DJ, juggling beats at a flashy Miami party while rocking a Simone Rocha dress that complements her honey-hued hair and brown eyes. By day she shifts into activist mode, traveling the country, giving interviews, talking at conferences and filming a documentary — all on the complex and controversial subject of medical marijuana. Leyland wants people to know how she has overcome a crippling neurological illness.
    zoe
  • What Causes Seizures? June 26, 2019 12:00 am
    A variety of different things may happen as a result of a seizure, depending upon the region of the brain that is affected. There may be sudden changes in sensory perception, such as visual disturbances or the smell of an unusual odor. There may be rapid and inexplicable emotional or cognitive changes. There are often involuntary muscle movements, and sometimes even complete loss of control over the movement of one’s body. Obviously, this could lead to serious consequences if someone has a seizure while, for example, driving a car.
    zoe
  • CBD for Brain-Damaged Babies? June 20, 2019 12:00 am
    Giving medical cannabis to infants is a difficult taboo to shift, but new research is paving the way. The launch of a clinical trial examining the use of CBD in newborns suffering from hypoxic ischemic encephalopathy (brain damage caused by lack of oxygen) means new hope for the million plus babies born each year with this condition.
    zoe
  • 5 CBD Secrets June 11, 2019 7:14 pm
    Cannabidiol and CBD oil seem to be everywhere these days, despite the confusing legal status of this prolific compound. But how much do we actually know about CBD?
    zoe
  • Tell the FDA What's on Your Mind June 5, 2019 8:31 pm
    The FDA is asking for input on how to regulate CBD and cannabis. Project CBD gave oral comments at last week’s public hearing, and we plan on submitting written comments and supporting documents to their public docket. You should, too.
    zoe
  • The FDA and Cannabis Regulation June 5, 2019 8:27 pm
    “My name is Zoe Sigman, and I’m the Program Director at Project CBD, an educational nonprofit focused on cannabis science & medicine. Ten years ago, we introduced CBD to the medical cannabis community in California. It spread like wildfire and has become the hugely popular phenomenon that it is today.
    zoe
  • Five Fallacies About Hemp May 22, 2019 5:55 pm
    It’s been six months since Congress passed the Farm Bill legalizing hemp for cultivation. It’s high time that we rectify some common myths about this plant.
    zoe
  • Cannabis: Gateway to Herbal Medicine May 15, 2019 5:00 pm
    The human endocannabinoid system (ECS) is so named because it responds to cannabis compounds.
    zoe