What experts have to say about the Endocannabinoid System

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“For decades, scientists and mental health physicians tried to figure out how THC worked on the brain and body,” explained Dr. Paul Song, Chief Medical Officer of Calyx Peak Companies via email. A significant breakthrough came with the discovery of the endocannabinoid system (ECS) in the late ‘80s and early ‘90s.

Additional research has since identified endocannabinoids as the cannabinoids produced within our own bodies. The endocannabinoid system regulates and interprets a series of processes in the body, including memory, pain, reproduction, appetite, immune function and many others. The two major endocannabinoids to be identified today are Anandamide and 2-AG, or Arachidonoylglycerol.

In an email to High Times, Katie Stem, CEO of Peak Extracts, gave a brief overview of the endocannabinoid system. “The system consists of two main receptor types: CB1 and CB2. The endocannabinoids are lipid-based neurotransmitters that elicit effects on the entire nervous system, from your brain to your fingertips.”

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A Physician’s Perspective on Optimal Cannabis Dosing

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Dosage is the key factor in achieving the most benefits and least adverse effects of cannabis. After following thousands of patients using medical cannabis for eight years, I’ve observed that dosing cannabis is unlike any therapeutic agent to which I was exposed in my medical training. A basic understanding of the key characteristics of cannabis dosing can empower you to make the most of this incredibly versatile, safe, and effective herb.

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Medical Marijuana for Rheumatoid Arthritis Pain: How to Talk to Your Doctor

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Have you ever discussed cannabis with your doctor? Despite the fact that 29 states plus the District of Columbia have decriminalized the use of marijuana for the treatment of certain medical problems, research published in September 2017 in Drug and Alcohol Dependence found that nine out of ten doctors were unprepared to prescribe it to their patients. “Most doctors don’t know much about it, even in the states where it is legal,” says Rav Ivker, DO, a holistic family physician in Boulder, Colorado and author of Cannabis for Chronic Pain: A Proven Prescription for Using Marijuana to Relieve Your Pain and Heal Your Life.

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No Brainer: CBD & THC for Head Injuries

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  • According to a U.S. government-held patent pertaining to “cannabinoids as antioxidants and neuroprotectants,” CBD and THC can limit “neurological damage following ischemic insults, such as stroke or trauma.”
  • A 2014 study found that traumatic brain injury (TBI) patients who tested positive for THC were more likely to survive with less impairment than TBI patients who abstained from marijuana.
  • Preclinical research and anecdotal accounts indicate that CBD is highly active against brain ischemia, modulating many of the molecular hallmarks of TBI pathology.
  • CBD normalizes post-ischemic heart arrhythmia and limits the size of damaged brain tissue in mice when administered shortly before or after a closed head injury.
  • CBD produces no intoxicating effects, no THC-like high, and its use does not lead to tolerance.
  • As yet there have been no FDA-approved clinical trials to determine the efficacy of CBD-rich cannabis oil extracts for traumatic brain injury.

First Clinical Trial Of Cannabis For PTSD in Veterans Is Now Complete

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After a decade of working on the first FDA-approved trial examining the effects of THC and CBD on the symptoms of PTSD in war veterans, a team of researchers has declared their clinical trial complete. The process, however, was not simple.

“We are proud to have persevered through these regulatory hurdles independently of hospitals, universities, or the VA system,” commented site principal investigator Dr. Sue Sisley in a press release.

The Multidisciplinary Association for Psychedelic Studies (MAPS) received approval from the U.S. Public Health Service to start the study back in 2014. Research began in January 2017 at Phoenix, Arizona’s Scottsdale Research Institute, and was slated to also take place at Johns Hopkins University, until the school dropped out of the experiment in March 2017.

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What Is Caryophyllene and What Does This Cannabis Terpene Do?

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Terpenes provide a wide variety of aromatic properties ranging from floral and earthy notes to musky and citrusy ones. When it come to the spicier side of the spectrum, caryophyllene holds the trophy for the most flair.

The terpene caryophyllene is present in many herbs and spices, including black pepper, basil, and oregano, and cannabis strains with high levels of it deliver a spicy, funky warmth to the nose, similar to cinnamon and cloves.

What makes caryophyllene an intriguing terpene is its relationship with our endocannabinoid system, particularly, its ability to bind to CB2 receptors. Because of this, it comes with a host of potential medical benefits.

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A Patient’s Guide to Using Cannabis for Cancer

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The cannabis plant contains a number of compounds with research-backed benefits for cancer patients. The science-based case that it is a safe and effective medicine will be made below, with plenty of links to double-blind studies, authoritative sources, and leading experts. The takeaway being that the plant and preparations derived from it can provide relief of cancer-related symptoms like pain, nausea, and inflammation. Some research has even shown that some cannabis compounds may slow cancer growth and shrink tumors.

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When To Use Cannabis as a Substitute for Pharmaceuticals

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Medical marijuana advocates have celebrated cannabis as a non-toxic, non-addictive alternative to a wide range of prescription drugs. But while scores of patients have had success using cannabis as a substitute for pharmaceuticals, it’s not for everybody.

For one, not every patient responds to cannabis in the same way. Though many have reported using cannabis to alleviate anxiety, for example, others experience heightened anxiety and paranoia when they smoke weed.

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